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FLASH GENE
Symbol NPY1R contributors: mct - updated : 03-05-2014
HGNC name neuropeptide Y receptor Y1
HGNC id 7956
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
HOMOLOGY
Homologene
FAMILY G protein coupled receptor superfamily,rhodopsin-like
CATEGORY immunity/defense , receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • possible role for NPY1R-expressing dorsal horn neurons in pain
  • NPY system, via NPY1R, directly inhibits the differentiation of mesenchymal progenitor cells as well as the activity of mature osteoblasts
  • is a modulator of pulpal inflammation
  • direct role on osteoblasts in the regulation of osteoblast activity and bone formation
  • in immune cells regulates inflammation and insulin resistance associated with diet-induced obesity
  • role for NPY1R axis as a regulator of bone homeostasis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS behavioral , nervous system
    text
  • feeding behavior
  • electrogenic ion transport
    • PATHWAY
    metabolism
    signaling signal transduction
    isolated tumor colon
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding neuropeptide Y (NPY) and peptide YY (PYY), pancreatic polypeptide (PP°
  • receptor for PRLH
  • interaction between NPY1R and NPY5R in the regulation of energy homeostasis
  • Ghrelin interacts with NPY1R and opioid receptors to increase food reward
  • BMP2 signaling regulates NPY1R expression, and raises the possibility that NPY acts in osteoblasts via an autocrine mechanism
  • regulation of NPY1R expression by BMP2 depends on the SMAD1/4 signaling pathway
    • cell & other
    REGULATION
    Other inducing the expression of CRE containing target genes through the CaM kinase-CREB pathway and inhibiting CRE containing genes when cellular cAMP is elevated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    delays fracture healing, through impairing the early phases of fracture repair to achieve bony union
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • global or osteoblast-specific Npy1r deletion induces pronounced bone anabolic effects in mice