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FLASH GENE

Symbol

NPY1R

contributors: mct - updated : 03-05-2014

HGNC name	neuropeptide Y receptor Y1
HGNC id	7956

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE
text	overlapping NPY5R,in opposite orientation
STRUCTURE	20.87 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000909 3 - 2974 NP_000900 - 393 - 1997 9169155

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine         Nervous brain forebrain cerebral cortex       brain basal nuclei striatum     Reproductive male system testis       Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory digestive epithelium     Epithelial barrier/lining uroepithelium     Epithelial secretory glandular exocrine   Nervous central

cells

System Cell Pubmed Species Stage Rna symbol Skeleton osteoblast Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

HOMOLOGY

Homologene

FAMILY

G protein coupled receptor superfamily,rhodopsin-like

CATEGORY

immunity/defense , receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	possible role for NPY1R-expressing dorsal horn neurons in pain
	NPY system, via NPY1R, directly inhibits the differentiation of mesenchymal progenitor cells as well as the activity of mature osteoblasts
	is a modulator of pulpal inflammation
	direct role on osteoblasts in the regulation of osteoblast activity and bone formation
	in immune cells regulates inflammation and insulin resistance associated with diet-induced obesity
	role for NPY1R axis as a regulator of bone homeostasis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

behavioral , nervous system

text	feeding behavior
	electrogenic ion transport

PATHWAY

metabolism

signaling

signal transduction

isolated tumor colon

a component

INTERACTION

DNA

RNA

small molecule

protein	binding neuropeptide Y (NPY) and peptide YY (PYY), pancreatic polypeptide (PP°
	receptor for PRLH
	interaction between NPY1R and NPY5R in the regulation of energy homeostasis
	Ghrelin interacts with NPY1R and opioid receptors to increase food reward
	BMP2 signaling regulates NPY1R expression, and raises the possibility that NPY acts in osteoblasts via an autocrine mechanism
	regulation of NPY1R expression by BMP2 depends on the SMAD1/4 signaling pathway

cell & other

REGULATION

Other

inducing the expression of CRE containing target genes through the CaM kinase-CREB pathway and inhibiting CRE containing genes when cellular cAMP is elevated

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   delays fracture healing, through impairing the early phases of fracture repair to achieve bony union

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

global or osteoblast-specific Npy1r deletion induces pronounced bone anabolic effects in mice