Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NPY1R contributors: mct - updated : 03-05-2014
HGNC name neuropeptide Y receptor Y1
HGNC id 7956
Location 4q32.2      Physical location : 164.245.116 - 164.253.748
Synonym symbol(s) NPYR1, NPY1-R, NPYR
DNA
TYPE functioning gene
SPECIAL FEATURE
text overlapping NPY5R,in opposite orientation
STRUCTURE 20.87 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2974 - 393 - 1997 9169155
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine    
Nervousbrainforebraincerebral cortex  
 brainbasal nucleistriatum  
Reproductivemale systemtestis    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium  
Epithelialbarrier/lininguroepithelium  
Epithelialsecretoryglandularexocrine 
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Skeletonosteoblast Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
HOMOLOGY
Homologene
FAMILY G protein coupled receptor superfamily,rhodopsin-like
CATEGORY immunity/defense , receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • possible role for NPY1R-expressing dorsal horn neurons in pain
  • NPY system, via NPY1R, directly inhibits the differentiation of mesenchymal progenitor cells as well as the activity of mature osteoblasts
  • is a modulator of pulpal inflammation
  • direct role on osteoblasts in the regulation of osteoblast activity and bone formation
  • in immune cells regulates inflammation and insulin resistance associated with diet-induced obesity
  • role for NPY1R axis as a regulator of bone homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS behavioral , nervous system
    text
  • feeding behavior
  • electrogenic ion transport
  • PATHWAY
    metabolism
    signaling signal transduction
    isolated tumor colon
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding neuropeptide Y (NPY) and peptide YY (PYY), pancreatic polypeptide (PP°
  • receptor for PRLH
  • interaction between NPY1R and NPY5R in the regulation of energy homeostasis
  • Ghrelin interacts with NPY1R and opioid receptors to increase food reward
  • BMP2 signaling regulates NPY1R expression, and raises the possibility that NPY acts in osteoblasts via an autocrine mechanism
  • regulation of NPY1R expression by BMP2 depends on the SMAD1/4 signaling pathway
  • cell & other
    REGULATION
    Other inducing the expression of CRE containing target genes through the CaM kinase-CREB pathway and inhibiting CRE containing genes when cellular cAMP is elevated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    delays fracture healing, through impairing the early phases of fracture repair to achieve bony union
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • global or osteoblast-specific Npy1r deletion induces pronounced bone anabolic effects in mice