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FLASH GENE

Symbol

FIGLA

contributors: mct/ - updated : 25-03-2021

HGNC name	folliculogenesis specific basic helix-loop-helix
HGNC id	24669

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001004311 5 - 722 NP_001004311 24.1 219 - 2008 18499083

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)

cells

System Cell Pubmed Species Stage Rna symbol Reproductive germ cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	ovary only

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	transcription factor essential for oocytes to survive and form primordial follicles
	involved in continued oocyte survival as primordial follicles
	its physiological expression plays a critical dual role in activation of oocyte-associated genes and repression of sperm-associated genes during normal postnatal oogenesis
	regulating expression of zona pellucida genes as well as that of other oocytes-specific genes
	represses genes that are expressed normally in the testis
	bHLH transcription factor, sustaining the female phenotype by activating female and repressing male germ cell genetic hierarchies in growing oocytes during postnatal ovarian development
	FIGLA, LHX8, NOBOX, SOHLH1, and SOHLH2 transcriptional regulators are critical for formation and maintenance of follicles
	major role for FIGLA, LHX8 and SOHLH1 as multifunctional regulators of networks necessary for oocyte maintenance and differentiation during early folliculogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heterodimerizing with TCF3

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

POF6

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   haploinsufficiency causes premature ovarian failure by disrupting formation of primordial follcules

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS