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FLASH GENE
Symbol SSTR3 contributors: mct/shn - updated : 24-08-2017
HGNC name somatostatin receptor 3
HGNC id 11332
Location 22q12.3      Physical location : 37.602.245 - 37.608.353
Synonym name somatostatin receptor type 3
Synonym symbol(s) SS-3-R, SS3-R, SS3R, SSR-28
DNA
TYPE functioning gene
STRUCTURE 16.21 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D22S1045 - D22S445 - SSTR3 - D22S1156 - D22S272 - qter
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 3764 - 418 - 1992 1337145
2 - 2123 - 418 - 1992 1337145
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbraincerebellum predominantly Homo sapiens
 brainforebraincerebral cortex moderately Homo sapiens
 brainlimbic systemhippocampus predominantly Homo sapiens
Olfactory (smell)olfactory bulb   predominantly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...)
cell lineage
cell lines HEK 293 human embryonal kidney cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • HOMOLOGY
    interspecies ortholog to SSTR3, Pan troglodytes
    ortholog to Sstr3, Rattus norvegicus
    ortholog to Sstr3, Mus musculus
    Homologene
    FAMILY
  • G protein-coupled receptors
  • superfamily of somatostatin receptors (SSTR)
  • CATEGORY signaling hormone , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase
  • in an appropriate cellular environment, can functionally couple to the inhibition of adenylyl cyclase
  • might play a role in the growth and apoptosis of gastric cancer
  • can activate G-proteins locally at tight junctions
  • directly recognized by the BBSome in order to mediate targeting of membrane proteins to cilia
  • SSTR3- mediated intracellular signaling and apoptosis is regulated by its cytoplasmic terminal
  • selectively targeted to primary cilia on neurons in the mammalian brain and is implicated in learning and memory 6)
  • regulates antiproliferative signaling and apoptosis in several cells
  • might exert its pro-apoptotic function on neuronal apoptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • functionally coupled to adenylyl cyclase
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Gi alpha 1
  • constitutive SSTR3 activity mediates transcriptional repression of GH1 through cAMP/PKA, leading to subsequent activation of GSK3B and increased POU1F1 phosphorylation
  • role for ARRB2 in the mediation of SSTR3 ciliary signaling
  • B9D1, AHI1, and the N termini of NPHP4 and IQCB1 interact with the transmembrane protein SSTR3 and thus spatially map to the outer region of the ciliary gating zone
  • cell & other
    REGULATION
    Other regulated by RAB21, that regulates SSTR3 trafficking
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer compared with normal mucosa
    tumoral     --over  
    in T-leukaemia cell lines
    tumoral     --over  
    in non-functioning pituitary adenomas (NFPA), compared to those in somatotropinomas and in normal pituitaries
    tumoral     --low  
    in silent corticotroph adenomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    tumor  
    DRD2 and SSTR3 seem to be the most promising targets for pharmacological treatment of pituitary adenomas
    immunologyinflammatory 
    useful targets for therapy during inflammatory diseases and malignancies affecting lymphocytes
    ANIMAL & CELL MODELS