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FLASH GENE

Symbol

TAL1

contributors: mct/npt/pgu - updated : 10-06-2016

HGNC name	T-cell acute lymphocytic leukemia 1
HGNC id	11556

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

TAL1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     translocation t(1;14) (p34,q11) or deletion in T cell acute lymphoblastic leukemia with worse response to treatment tumoral       gain of function Aberrant activation is involved in up to 60p100 of T cell acute lymphoblastic leukemia (T-ALL) cases, indicating that misregulation of TAL1's activity may lead to the development of T cell leukemia tumoral     --other   with LYL1, aberrantly over-expressed in leukemia as a result of chromosomal translocations tumoral     --low   by aberrant methylation of TAL1 in pediatric B-cell acute lymphoblastic leukemia (pMID: 25830127) tumoral       gain of function aberrant TAL1 activation is mediated by an interchromosomal interaction in human T-cell acute lymphoblastic leukemia

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS