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FLASH GENE

Symbol

CYP24A1

contributors: mct - updated : 29-04-2014

HGNC name	cytochrome P450, family 24, subfamily A, polypeptide 1
HGNC id	2602

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in lung tumors restricts 1,25D3 activity and support the preclinical evaluation of CYP24 inhibitors for lung cancer treatment tumoral     --over   in renal cell carcinoma constitutional germinal mutation       bi-allelic mutations in CYP24A1 causes elevated serum vitamin D, hypercalciuria, nephrocalcinosis, and renal stones

Susceptibility

to vitamin D response variation in postmenopausal women

Variant & Polymorphism other	DNA methylation levels of CYP24A1 predict vitamin D response variation in postmenopausal women

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive colon selective inhibition of CYP24A1 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on colorectal cancer

ANIMAL & CELL MODELS

in fracture repair, delay in the mineralization of the cartilaginous matrix of the soft callus in Cyp24a1 -/- mutant animals, accompanied by reduced expression of chondrocyte marker genes