Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CDC25A

contributors: mct - updated : 10-09-2014

HGNC name	cell division cycle 25 homolog A (S. pombe)
HGNC id	1725

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   associated with spermatogenic failure and failed sperm retrieval in infertile men constitutional     --over   initiates centrosome separation by activation of centrosomal Cdk1/Cyclin B pools tumoral     --over   in breast cancer cells enhances metastasis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast anti-Cdc25A strategy may reveal its therapeutic potential in prevention and treatment of breast cancer cell dissemination digestive liver   pharmacological targeting of CDC25A has therapeutic potential in polycystic liver diseases

ANIMAL & CELL MODELS

CDC25A-deficient embryos exhibit growth retardation and die before E7.5 through an apoptotic pathway