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FLASH GENE
Symbol GZMH contributors: - updated : 17-03-2006
HGNC name granzyme H (cathepsin G-like 2, protein h-CCPX)
HGNC id 4710
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • a peptidase S1 domain
  • three sites of glycosylation
    • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Gzmg
    ortholog to rattus Rnkp7
    Homologene
    FAMILY
  • peptidase S1 family
  • granzyme subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text
  • cytoplasmic granules of cytolytic T-lymphocytes
    • basic FUNCTION
  • may be necessary for target cell lysis in cell-mediated immune responses
  • involved in cytolysis
  • acting as a serine-type endopeptidase
    • CELLULAR PROCESS cell life, cell death/apoptosis
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS