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FLASH GENE
Symbol GZMH contributors: - updated : 17-03-2006
HGNC name granzyme H (cathepsin G-like 2, protein h-CCPX)
HGNC id 4710
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon lowly
Urinarykidney   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/HematopoieticNK cell
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • a peptidase S1 domain
  • three sites of glycosylation
    • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Gzmg
    ortholog to rattus Rnkp7
    Homologene
    FAMILY
  • peptidase S1 family
  • granzyme subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text
  • cytoplasmic granules of cytolytic T-lymphocytes
    • basic FUNCTION
  • may be necessary for target cell lysis in cell-mediated immune responses
  • involved in cytolysis
  • acting as a serine-type endopeptidase
    • CELLULAR PROCESS cell life, cell death/apoptosis
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS