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FLASH GENE

Symbol

GZMH

contributors: - updated : 17-03-2006

HGNC name	granzyme H (cathepsin G-like 2, protein h-CCPX)
HGNC id	4710

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster, tail to tail
text	clustered with cathepsin G and CTSGL1
STRUCTURE	3.00 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   lowly Urinary kidney       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic NK cell Lymphoid/Immune lymphocyte

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal peptide
	a peptidase S1 domain
	three sites of glycosylation

conjugated

GlycoP

isoforms

Precursor

HOMOLOGY

interspecies	homolog to murine Gzmg
	ortholog to rattus Rnkp7

Homologene

FAMILY	peptidase S1 family
	granzyme subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic,granule
text	cytoplasmic granules of cytolytic T-lymphocytes

basic FUNCTION	may be necessary for target cell lysis in cell-mediated immune responses
	involved in cytolysis
	acting as a serine-type endopeptidase

CELLULAR PROCESS	cell life, cell death/apoptosis
	protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS