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FLASH GENE

Symbol

GTF2E1

contributors: mct - updated : 08-03-2018

HGNC name	general transcription factor IIE, polypeptide 1, alpha 56kDa
HGNC id	4650

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3q13.33      Physical location : 120.461.557 - 120.501.915
Synonym symbol(s)	TF2EA, TF2E1, FE, TFIIE-A

DNA

TYPE	functioning gene
STRUCTURE	40.36 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005513 3033 - 5 NP_005504 - 439 - 2015 25492609

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     highly Lymphoid/Immune thymus       highly Reproductive male system testis     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	zinc finger motif, essential for its function, particularly in the transition from the transcription initiation to elongation and the conformational tuning of this domain for appropriate positioning of TFIIF, TFIIH, and polymerase II would be needed depending on the situation and timing
	leucine repeat
	three-winged helix (WH) motifs, with one in GTF2E1 and two in GTF2E2

secondary structure

helix-turn-helix

mono polymer

heteromer , tetramer

HOMOLOGY

interspecies	homolog to murine Gtf2e1
	homolog to C.elegans Zk550.4

Homologene

FAMILY

TFIIE alpha subunit family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm

basic FUNCTION	involved in the regulation of transcription inhitiation
	T2FH recruitment to initiation complex
	stimulating the RNA polymerase II C terminal domain kinase and RNA dependent ATPase activities of TFIIH
	has essential roles in both transcription initiation and promoter escape
	POLR3C as well as GTF2E1 possess intrinsic ATP-dependent 3'-5' DNA unwinding activity

CELLULAR PROCESS	nucleotide, transcription, initiation
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heterotetramer of two alpha and two beta chains

INTERACTION

DNA

RNA

small molecule	metal binding,
	zinc Zn2+

protein	GTF2H1 is recruited to the transcription preinitiation complex through an interaction between its p62/Tfb1 subunit and the alpha-subunit of GTF2E1
	GTF2E1 and TP53 share the binding region on GTF2H1
	CDK7 thus acts through GTF2E1, GTF2E2 and SUPT5H to establish, and through CDK9 to relieve, barriers to elongation
	GTF2E2 binds to the WH domain of GTF12E1 via its bHLH domain (basic region-helix-loop-helix motif, AAs 193–240)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS