Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ALKAL1 contributors: mct - updated : 25-10-2019
HGNC name ALK and LTK ligand 1
HGNC id 33775
Location 8q11.23      Physical location : -
Synonym name
  • hypothetical protein LOC389658
  • augmentor-beta
  • family with sequence similarity 150, member A
    • Synonym symbol(s) UNQ9433, MGC163513, MGC163515, RPLK9433, FAM150A, AUGB,
    DNA
    TYPE functioning gene
    STRUCTURE 31.39 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1140 - 129 - 2015 26630010
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal variable region
  • a conserved C-terminal augmentor domain (AD)
    • HOMOLOGY
    Homologene
    FAMILY
  • FAM150 family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • physiological link between augmentor ligands (FAM150A, FAM150B) and LTK and particular augmentors activate LTK in a tissue-specific context to induce iridophore differentiation from neural crest-derived cells and pigment progenitor cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ALKAL1 stimulates LTK phosphorylation in a ligand-dependent manner
  • ALKAL1 and ALKAL2 are potent ligands for human ALK that bind to the extracellular domain of ALK and in addition to activation of wild-type ALK are able to drive 'superactivation' of activated ALK mutants from neuroblastoma
  • ALKAL1 is specific for LTK and only weakly binds to ALK
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS