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FLASH GENE
Symbol RUBCN contributors: mct/shn - updated : 10-06-2016
HGNC name KIAA0226
HGNC id 28991
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains RH domain
HOMOLOGY
interspecies ortholog to 1700021K19Rik, Mus musculus
Homologene
FAMILY
CATEGORY motor/contractile
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,endosome
intracellular,cytoplasm,organelle,lysosome
text localized at the endosome/lysosome
basic FUNCTION
  • negatively regulates both the autophagic and endocytic pathways (
  • prevents endosome maturation through differential interactions with RAB7A and UVRAG
  • serves as a previously unknown RAB7A effector to ensure the proper progression of the endocytic pathway
  • key negative regulator in endosome maturation
  • critical function in endocytic trafficking, which is to control the endosome maturation by regulating RAB7A and UVRAG
  • RUBCN acts as a negative regulator for virus-triggered IFN signaling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component component of the PI3KC3 complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Rab7 and PI3-kinase (
  • interacting with RAB7A, and UVRAG (GTP-bound RAB7A competes with UVRAG for RUBICON binding)
  • Beclin 1-interacting protein
  • RUBCN interacts with IRF3 and ultimately this interaction leads to inhibition of the dimerization of IRF3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCAR15
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS