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FLASH GENE
Symbol SPIDR contributors: mct - updated : 02-09-2015
HGNC name scaffolding protein involved in DNA repair
HGNC id 28971
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • through providing a scaffold for the cooperation of BLM and RAD51 in a multifunctional DNA-processing complex, SPIDR not only regulates the efficiency of HR, but also dictates the specific HR pathway
  • SPIDR is the link between BLM and the HR machinery
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SPIDR independently interacts with BLM and RAD51 and promotes the formation of a BLM/RAD51-containing complex of biological importance
  • binding partner of FIGNL1 and acts with FIGNL1 in HR repair
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS