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FLASH GENE

Symbol

SPIDR

contributors: mct - updated : 02-09-2015

HGNC name	scaffolding protein involved in DNA repair
HGNC id	28971

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001080394 20 - 3396 NP_001073863 100 915 - - NM_001282916 19 - 3329 NP_001269845 - 845 - - NM_001282919 19 - 3360 NP_001269848 - 876 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

HOMOLOGY

Homologene

FAMILY

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	through providing a scaffold for the cooperation of BLM and RAD51 in a multifunctional DNA-processing complex, SPIDR not only regulates the efficiency of HR, but also dictates the specific HR pathway
	SPIDR is the link between BLM and the HR machinery

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	SPIDR independently interacts with BLM and RAD51 and promotes the formation of a BLM/RAD51-containing complex of biological importance
	binding partner of FIGNL1 and acts with FIGNL1 in HR repair

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS