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FLASH GENE
Symbol EPHA3 contributors: mct/npt - updated : 08-07-2011
HGNC name EPH receptor A3
HGNC id 3387
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a vestigial Ig-l domain
  • a single cystein rich region
  • two FNIII domains in the extracellular region
    • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • ephrin receptor
    • CATEGORY enzyme , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • involved in short-range contact-mediated axonal guidance
  • key players in controlling these cell movements in many tissues and at multiple stages of patterning
  • suppresses motility through regulation of Rho GTPases in rhabdomyosarcoma cells
  • mediate processes involving cell-cell contact, including cellular adhesion or repulsion, developmental remodeling and neuronal mapping
  • EPHA3 and PROM1 may play an important role in the development and progression of colorectal tumours
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EPH-related tyrosine kinase receptor binding ephrins A
  • EPHA3-PTPN1 interaction can occur directly at the plasma membrane
    • cell & other
    REGULATION
    induced by CD28 and IGF-1 and regulates cell adhesion
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in breast, lung, and pancreatic cancers
    tumoral     --other  
    not detected in normal peripheral T cells, in any subset of thymus-derived developing T cells, or in Hodgkin's lymphoma, but detected in a panel of T-cell lymphomas
    tumoral     --over  
    associated with lymphocytic leukaemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker useful indicators for clinical assessment of tumour biological behaviour and prognosis in patients with colorectal carcinoma
    Therapy target
    ANIMAL & CELL MODELS