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FLASH GENE

Symbol

EPHA3

contributors: mct/npt - updated : 08-07-2011

HGNC name	EPH receptor A3
HGNC id	3387

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p11.2      Physical location : 89.156.673 - 89.531.282
Synonym name	EPH-related tyrosine kinase receptor 3
	eph-like tyrosine kinase 1
	TYRO4 protein tyrosine kinase
Synonym symbol(s)	ETK1, HEK, ETK, HEK4, TYRO4
EC.number	2.7.10.1

DNA

TYPE	functioning gene
STRUCTURE	374.61 kb     17 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005233 17 - 5837 110 983 - 2004 14697337 NM_182644 7 - 2684 - 539 - 2004 14697337

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Reproductive female system placenta     highly   male system prostate     highly Respiratory respiratory tract trachea     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage	some pre-B and T cell lines
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a vestigial Ig-l domain
	a single cystein rich region
	two FNIII domains in the extracellular region

HOMOLOGY

Homologene

FAMILY	protein kinase superfamily
	Tyr protein kinase family
	ephrin receptor

CATEGORY

enzyme , receptor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	involved in short-range contact-mediated axonal guidance
	key players in controlling these cell movements in many tissues and at multiple stages of patterning
	suppresses motility through regulation of Rho GTPases in rhabdomyosarcoma cells
	mediate processes involving cell-cell contact, including cellular adhesion or repulsion, developmental remodeling and neuronal mapping
	EPHA3 and PROM1 may play an important role in the development and progression of colorectal tumours

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	EPH-related tyrosine kinase receptor binding ephrins A
	EPHA3-PTPN1 interaction can occur directly at the plasma membrane

cell & other

REGULATION

induced by

CD28 and IGF-1 and regulates cell adhesion

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       in breast, lung, and pancreatic cancers tumoral     --other   not detected in normal peripheral T cells, in any subset of thymus-derived developing T cells, or in Hodgkin's lymphoma, but detected in a panel of T-cell lymphomas tumoral     --over   associated with lymphocytic leukaemia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	useful indicators for clinical assessment of tumour biological behaviour and prognosis in patients with colorectal carcinoma
Therapy target

ANIMAL & CELL MODELS