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FLASH GENE
Symbol PTX3 contributors: mct - updated : 29-06-2010
HGNC name pentraxin 3, long
HGNC id 9692
Location 3q25.32      Physical location : 157.154.579 - 157.161.416
Synonym name
  • tumor necrosis factor, alpha-induced protein 5
  • pentaxin-related protein PTX3
  • pentraxin-related gene, rapidly induced by IL-1 beta
  • TNF alpha-induced protein 5
  • Synonym symbol(s) TSG14, TNFAIP5
    DNA
    TYPE functioning gene
    STRUCTURE 6.84 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1955 - 381 - 2009 19900712
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrineneuroendocrinepituitary  highly
    Nervousbrainforebraincerebral lobefrontal 
    Reproductivefemale systemplacenta  highly
    Respiratorylung   highly
    Urinarykidneytubuleconvoluted tubuleproximal tubulehighly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectivebone  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinaryepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • cysteine residues at positions 47, 49, and 103 in the N-terminal region form three homotypic interchain disulfide bonds holding four protein subunits in a tetrameric arrangement
  • a putative signal peptide
  • a pentraxin domain
  • two FGF2 binding sites, in PTX3 octamer
  • C-terminal domain required for C1q recognition and complement activation and containing a single N-glycosylation site on Asn 220
  • conjugated GlycoP
    mono polymer homomer , octamer
    HOMOLOGY
    interspecies homolog to murine Ptx3
    Homologene
    FAMILY
  • pentaxin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    text
  • key component of the hyaluronan-rich cumulus extracellular matrix, which forms around the oocyte prior to ovulation
  • basic FUNCTION
  • playing a role in the inflammatory response (antifungal innate immune response)
  • playing key roles in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility
  • may play a role in the innate immune response and inflammatory reactions in the kidney
  • fluid-phase pattern recognition receptor that plays a nonredundant role in innate immunity and female fertility
  • involved in C1q recognition and complement activation
  • multifunctional soluble pattern recognition receptor acting as a non-redundant component of the humoral arm of innate immunity involved in fine-tuning inflammation, matrix deposition, angiogenesis and, in particular, in female fertility
  • translocates at the surface of late apoptotic neutrophils and acts as an 'eat-me' molecule for their recognition and capture by macrophages
  • coordinated expression of PTX3 and TNFAIP6 may play a role in ECM remodeling at sites of inflammation
  • important role in innate immune responses and in female fertility
  • participates in the attenuation of macrophage-mediated phagocytosis of damaged neuron cells
  • role for astrocytic CEBPD and the CEBPD-regulated molecule PTX3 in the accumulation of damaged neurons, which is a hallmark of Alzheimer disease pathogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    text inflammatory response
    PATHWAY
    metabolism
    signaling
    a component
  • homomultimer, disulfide-linked
  • being mainly composed of covalently linked octamers
  • composed of multiple protomers, each composed of distinct N- and C-terminal domains (eight identical protomers, associated through disulfide bonds, forming an elongated and asymmetric, molecule with two differently sized domains interconnected by a stalk)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TNFAIP6 (coordinated expression of PTX3 and TNFAIP6 may play a role in ECM remodeling at sites of inflammation)
  • CEBPD target in astrocytes
  • binds to the classical and lectin pathway regulator C4b-binding protein (C4BPA)
  • cell & other
    REGULATION
    induced by IL1B
    TNFA
    estradiol and progesterone that are involved in PTX3 induction and regulation during embryo implantation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    elevated serum PTX3 levels are associated with the disease severity of systemic sclerosis
    Susceptibility to pulmonary tuberculosis
    Variant & Polymorphism other polymorphisms increasing the risk of pulmonary tuberculosis in addition with CD209
    Candidate gene amniotic fluid pentraxin 3 appears to be a marker of intra-amniotic inflammation
    Marker
    Therapy target
    ANIMAL & CELL MODELS