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FLASH GENE
Symbol RASEF contributors: mct/npt - updated : 02/06/2008
HGNC name RAS and EF-hand domain containing
HGNC id 26464
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a coiled-coil motif at the mid region
  • a distinct N-terminal EF-hand domain
  • a domain found in RAS family GTP-binding proteins
  • Ras GTPase (Rab family) motifs at the C-terminus, that bound guanine nucleotide tri- and di-phosphates
    • HOMOLOGY
    Homologene
    FAMILY
  • small GTPase superfamily
  • Rab family
    • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • potentially involved in the RAS pathway prominent in the development of melanoma
  • capable of self-interacting, and the self-interaction required the mild region containing the coiled-coil motif
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    homozygosity and methylation in primary primary uveal melanomas were associated with decreased survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS