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FLASH GENE

Symbol

TMEM43

contributors: mct/npt - updated : 27-08-2012

HGNC name	transmembrane protein 43
HGNC id	28472

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	like-sequence
STRUCTURE	18.00 kb     12 Exon(s)

regulatory sequence	Promoter
	Binding site
text structure	contains a response element for PPARgamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium

MAPPING

cloned

Y

linked

N

status

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 12 - 3254 44.8 400 - Merner (208)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Homo sapiens Digestive mouth       highly Reproductive female system uterus     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly Muscular striatum cardiac myocardium   Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Tmem43

Homologene

FAMILY

TMEM43 family

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION

unknown

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

adipogenic pathway regulated by PPARgamma

a component

INTERACTION

DNA

RNA

small molecule

protein

target of PPARgamma

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ARVD5

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS