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FLASH GENE
Symbol REG3A contributors: mct - updated : 16-12-2013
HGNC name regenerating islet-derived 3 alpha
HGNC id 8601
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one c-type lectin family domain
HOMOLOGY
Homologene
FAMILY Reg-related family
CATEGORY secretory
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm
basic FUNCTION
  • may be a stress protein involved in the control of bacterial proliferation
  • inducing new pancreatic islets development
  • stimulates beta-cell replication, by activating Akt kinase and increasing the levels of CCND1/CDK4
  • secreted intestinal antimicrobial protein, can promote skin keratinocyte proliferation
  • may potentially mediate the epidermal hyperproliferation observed in normal wound repair and in psoriasis
  • downstream mediator of IL17A that enhances keratinocyte proliferation and downmodulates keratinocyte differentiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDX-1 binds directly to the INGAP promoter (in a possible feedback loop to block unbridled pancreatic islet expansion)
  • phosphorylated in response to extracellular stimuli by action of MAP3K1
    • cell & other
    REGULATION
    induced by interleukin-17 (IL17) via activation of keratinocyte-encoded IL17 receptor A (IL-17RA)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in ulcerative colitis and Crohn's disease,in primary liver cancerin acute or chronic pancreatitis
    tumoral     --low  
    in gastric cancer
    constitutional     --over  
    in keratinocytes during psoriasis and wound repair
    Susceptibility
    Variant & Polymorphism
    Candidate gene for the treatment of diabetes
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 1 
    can serve as novel targets in diabetes mellitus genetic therapy
    ANIMAL & CELL MODELS