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FLASH GENE

Symbol

REG3A

contributors: mct - updated : 16-12-2013

HGNC name	regenerating islet-derived 3 alpha
HGNC id	8601

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	2.75 kb     5 Exon(s)

regulatory sequence	Promoter (CAAT box) (TATA box)
	Binding site   transcription factor
text structure	stimulus-responsive DNA elements
	regulators of INGAP expression include the transcription factors PDX-1, NeuroD, PAN-1, STAT and AP-1

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see REG3G

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_138937 6 - 807 NP_620354 - 175 - 2006 16963458 NM_138938 5 - 1117 NP_620355 - 175 - 2006 16963458 NM_002580 6 - 830 NP_002571 - 175 - 2006 16963458

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine           stomach         Endocrine pancreas       highly Mus musculus Adult Urinary bladder

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular     Mus musculus

cells

System Cell Pubmed Species Stage Rna symbol Digestive acinar Mus musculus Adult Endocrine islet cell (alpha,beta...) Mus musculus

cell lineage
cell lines
fluid/secretion	secretory pancreatic protein

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one c-type lectin family domain

HOMOLOGY

Homologene

FAMILY

Reg-related family

CATEGORY

secretory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm

basic FUNCTION	may be a stress protein involved in the control of bacterial proliferation
	inducing new pancreatic islets development
	stimulates beta-cell replication, by activating Akt kinase and increasing the levels of CCND1/CDK4
	secreted intestinal antimicrobial protein, can promote skin keratinocyte proliferation
	may potentially mediate the epidermal hyperproliferation observed in normal wound repair and in psoriasis
	downstream mediator of IL17A that enhances keratinocyte proliferation and downmodulates keratinocyte differentiation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	PDX-1 binds directly to the INGAP promoter (in a possible feedback loop to block unbridled pancreatic islet expansion)
	phosphorylated in response to extracellular stimuli by action of MAP3K1

cell & other

REGULATION

induced by

interleukin-17 (IL17) via activation of keratinocyte-encoded IL17 receptor A (IL-17RA)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in ulcerative colitis and Crohn's disease,in primary liver cancerin acute or chronic pancreatitis tumoral     --low   in gastric cancer constitutional     --over   in keratinocytes during psoriasis and wound repair

Susceptibility

Variant & Polymorphism

Candidate gene	for the treatment of diabetes
Marker
Therapy target
	System Type Disorder Pubmed diabete type 1   can serve as novel targets in diabetes mellitus genetic therapy

ANIMAL & CELL MODELS