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FLASH GENE
Symbol VASH2 contributors: mct - updated : 28-03-2008
HGNC name vasohibin 2
HGNC id 25723
DNA
TYPE functioning gene
STRUCTURE 40.00 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3580 - 311 - Gregory (2006)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Hearing/Equilibriumear    
Lymphoid/Immunethymus    
Reproductivefemale systemplacenta   
Respiratoryrespiratory tracttrachea   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to VASH1 (>50 p100)
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • exhibited antiangiogenic activity
  • implicated in negative regulatory system of angiogenesis genetically programmed in endothelial cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in combination with vasohibin-1, forms a novel family of angiogenesis inhibitors
    • cell & other
    REGULATION
    induced by the stimulation with VEGF or FGF2, and selectively affects on endothelial cells and inhibits angiogenesis
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS