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FLASH GENE
Symbol VASH2 contributors: mct - updated : 28-03-2008
HGNC name vasohibin 2
HGNC id 25723
Location 1q32.3      Physical location : 213.123.886 - 213.164.925
Synonym name
  • vascular endothelial growth factor (VEGF)-inducible endothelium-derived angiogenesis inhibitor 2
    • Synonym symbol(s) FLJ12505, RP11-275G3.1
    DNA
    TYPE functioning gene
    STRUCTURE 40.00 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3580 - 311 - Gregory (2006)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Hearing/Equilibriumear    
    Lymphoid/Immunethymus    
    Reproductivefemale systemplacenta   
    Respiratoryrespiratory tracttrachea   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to VASH1 (>50 p100)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • exhibited antiangiogenic activity
  • implicated in negative regulatory system of angiogenesis genetically programmed in endothelial cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in combination with vasohibin-1, forms a novel family of angiogenesis inhibitors
    • cell & other
    REGULATION
    induced by the stimulation with VEGF or FGF2, and selectively affects on endothelial cells and inhibits angiogenesis
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS