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FLASH GENE
Symbol EHHADH contributors: - updated : 13-10-2006
HGNC name enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
HGNC id 3247
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal dehydrogenase activity
  • two hydratase activities in the central part
  • a C terminal region of strong homology with sterol carrier protein
    • mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • bifunctional enzyme (matrix) including enoyl-CoA hydratase (3-hydroxyacyl-CoA-dehydratase) and 3-hydroxyacyl-CoA dehydrogenase
  • catalyzing the second and third step of peroxisomal fatty acid beta-oxidation of very long chain fatty acids, but not bile intermediates
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • peroxisomal beta-oxidation of very long chain fatty acids
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PBE
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS