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FLASH GENE
Symbol EHHADH contributors: - updated : 13-10-2006
HGNC name enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
HGNC id 3247
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Nervousbrain   moderately
Reproductivemale systemprostate  moderately
Respiratorylung   moderately
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal dehydrogenase activity
  • two hydratase activities in the central part
  • a C terminal region of strong homology with sterol carrier protein
    • mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • bifunctional enzyme (matrix) including enoyl-CoA hydratase (3-hydroxyacyl-CoA-dehydratase) and 3-hydroxyacyl-CoA dehydrogenase
  • catalyzing the second and third step of peroxisomal fatty acid beta-oxidation of very long chain fatty acids, but not bile intermediates
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • peroxisomal beta-oxidation of very long chain fatty acids
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PBE
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS