| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
|
| loss of function
|
|
by methylation in uterus breast, colon, brain carcinomas |
| tumoral
|
|
|
| loss of function
|
|
in renal clear cell carcinoma with poor prognosis |
| constitutional
|
|
| --low
|
|
|
in heart failure |
| tumoral
|
|
| --low
|
|
|
in uveal melanoma with metastases |
| constitutional
|
|
| --over
|
|
increased in the renal arteries and proximal tubules of subjects with diabetic nephropathy or chronic allograft nephropathy  |
| constitutional
|
|
| --low
|
|
|
is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SIRT1 |
| constitutional
|
|
| --low
|
|
|
during preadipocyte differentiation, the Sp1-dependent decrease in TIMP3 expression is required for the successful implementation of the adipocyte differentiation program |
| tumoral
|
|
|
|
|
|
silenced by promoter methylation in a consistent fraction of Papillary thyroid carcinoma |
| constitutional
|
|
| --low
|
|
|
increases inflammation and polarizes macrophages towards a more inflammatory phenotype resulting in increased atherosclerosis |
| constitutional
|
|
| --over
|
|
|
TIMP3 mRNA expression increases and TIMP3 protein is in the appropriate cellular layers to regulate proteolytic remodeling as the follicle progresses toward ovulation |
| constitutional
|
|
|
|
|
|
induces choroidal neovascularization by moderating the polarization of macrophages in age-related macular degeneration |
