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FLASH GENE
Symbol AMT contributors: mct - updated : 06-12-2016
HGNC name aminomethyltransferase (glycine cleavage system protein T)
HGNC id 473
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
glycine cleavage T protein domain
HOMOLOGY
Homologene
FAMILY the GCVT family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
basic FUNCTION
  • amino-methyltransferase, tetrahydrofolate (THF) dependent, catalyzing the third step of the glycine cleavage system
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NKH2 , GCE3
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • homozygous Amt(-/-) mice developed neural tube defects at high frequency