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FLASH GENE

Symbol

AMT

contributors: mct - updated : 06-12-2016

HGNC name	aminomethyltransferase (glycine cleavage system protein T)
HGNC id	473

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	5.90 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001164712 10 - 1955 NP_001158184 - 385 - 1994 8188235 NM_001164710 8 - 2083 NP_001158182 - 359 - 1994 8188235 NM_001164711 8 - 2047 NP_001158183 - 347 - 1994 8188235 NM_000481 9 - 2215 NP_000472 - 403 - 1994 8188235

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive mouth tongue       Lymphoid/Immune spleen           thymus         Nervous brain         Reproductive male system prostate       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial sensory visual

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

glycine cleavage T protein domain

HOMOLOGY

Homologene

FAMILY

the GCVT family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria

basic FUNCTION

amino-methyltransferase, tetrahydrofolate (THF) dependent, catalyzing the third step of the glycine cleavage system

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

NKH2 , GCE3

related resource

MITOP database

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

homozygous Amt(-/-) mice developed neural tube defects at high frequency