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FLASH GENE
Symbol SLC22A25 contributors: mct - updated : 05-01-2021
HGNC name solute carrier family 22, member 25
HGNC id 32935
Location 11q12.3      Physical location : 62.931.295 - 62.997.124
Synonym name
  • organic anion transporter UST6
  • putative UST1-like organic anion transporter
  • Synonym symbol(s) UST6, HIMTP, MGC120420
    DNA
    TYPE functioning gene
    STRUCTURE 81.26 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1644 - 547 - 2009 17714910
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • solute carrier family 22 (SLC22)
  • facilitator superfamily
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • organic ion transporter
  • OATS4 (SLC22A9, SLC22A10, SLC2A24, and SLC22A25) members are specifically associated with conjugated sex hormones
  • SLC22A10 and SLC22A25 are only linked to conjugated sex hormones, making them relatively mono-specific transporters
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to atrial fibrillation
    Variant & Polymorphism SNP
  • rs11231397 [G/C (R300T)] of SLC22A25 associated with atrial fibrillation
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS