| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
| fusion
| translocation
|
|
|
|
t(7;22)(p22;q12) ; see ETV1 |
| tumoral
| fusion
| translocation
|
|
|
|
t(21;22)(q22;q12) ; see ERG |
| tumoral
| fusion
| translocation
|
|
|
|
t(12;22)(q13;q12) with malignant melanomas of soft tissues (MMST) ; see ATF1 |
| tumoral
| fusion
| translocation
|
|
|
|
t(11;22)(p13;q12) with desmoplastic small round cell tumor ; see DSRCT |
| tumoral
| fusion
| translocation
|
|
|
|
t(9;22) (q22-q31;q12) with extraskeletal myxoid chondrosarcoma (EMC) ; see TEC |
| tumoral
| fusion
| translocation
|
|
|
|
t(17;22) (q12;q12) with undifferentiated sarcoma in infancy ; see E1AF |
| tumoral
| fusion
|
|
|
|
with DDIT3 in t(12;22), in myxoid liposarcoma  |
| tumoral
| fusion
|
|
|
|
|
with CREB1 in t(2;22)(q33;q12) in angiomatoid fibrous histiocytoma |
| tumoral
| fusion
|
|
|
|
|
with PBX1 in (1;22)(q23;q12) in myoepithelioma |
| tumoral
| fusion
|
|
|
|
|
with FLI1, t(11;22)(q24;q12) in Ewing sarcoma, cancer-specific molecule that binds to RHA essential for the function of EWS-FLI1 |
| tumoral
| fusion
|
|
|
|
|
wirh POU5F1 in t(6;22)(p21;q12) associated with bone and soft-tissue tumours resulting in a chimaeric molecule fusing the NTD (N-terminal domain) of the EWSR1 to the CTD (C-terminal domain) of POU5F1 embryonic gene |
| tumoral
| fusion
|
|
|
|
|
t(19;22)(q13;q12) leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma |
| tumoral
|
|
| --over
|
|
|
in liposarcoma |
| tumoral
| fusion
|
|
|
|
|
with ATF1 is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland |
| tumoral
| fusion
|
|
|
|
|
with CREB3L1, in small cell osteosarcoma |
| tumoral
| fusion
|
|
|
|
|
with YY1 genes in mesothelioma with t(14;22)(q32;q12) |
| tumoral
| fusion
|
|
|
|
|
EWSR1-VGLL1 gene fusion in a soft tissue malignant myoepithelial tumor |
