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FLASH GENE
Symbol MEX3B contributors: mct - updated : 16-12-2014
HGNC name mex-3 homolog B (C. elegans)
HGNC id 25297
DNA
TYPE functioning gene
STRUCTURE 4.37 kb     2 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 3534 - 569 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   predominantly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal nuclear export signal (NES)
  • two heterogenous nuclear ribonucleoprotein K homology (KH) domains
  • a C-terminal RING-type zinc finger
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Rkhd3 (97.5 pc)
    homolog to murine Rkhd3 (97.9 pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • predominantly expressed in the cytoplasm
  • shuttling between the cytoplasm and the nucleus through the CRM1 export pathway
    • basic FUNCTION
  • may be involved in post-transcriptional regulatory mechanisms
  • phosphoprotein that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1-dependent export pathway
  • MEX3B can attenuate FGF signaling and destabilize mRNAs for the FGF signaling components Syndecan 2 and ETS1
  • acts to regulate the cortical level of activated RAP1A, a small G protein controlling phagocytosis and cell-cell interaction, through the activation and transport of RAP1GAP
  • implicated in the spatial organization of the RAP1A pathway that orchestrates Sertoli cell functions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding through the KH domains
    small molecule metal binding,
  • Zn2+
    • protein
  • interaction with YWHA adaptors regulates the sorting of MEX3B RNA-binding protein to distinct classes of RNA granules
  • is involved in anteroposterior patterning of the neural plate
  • HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, DZIP3 and MEX3B, as well as with their respective ubiquitination substrates, ATXN1 and SNUPN
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • seminiferous tubules of Mex3b-deficient mice are obstructed as a consequence of the disrupted phagocytic capacity of somatic Sertoli cells