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FLASH GENE
Symbol PDZD11 contributors: mct - updated : 23-08-2011
HGNC name PDZ domain containing 11
HGNC id 28034
Location Xq13.1      Physical location : 69.506.210 - 69.509.798
Synonym name
  • ATPase-interacting PDZ protein
  • plasma membrane calcium ATPase-interacting single-PDZ protein
  • Synonym symbol(s) RP13-26D14.3, AIPP1, PDZK11, PISP
    DNA
    TYPE functioning gene
    STRUCTURE 3.59 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1246 - 140 - 2005 16051599
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
     parathyroid   highly
    Reproductivefemale systemovary  highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • little else besides a single PDZ domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • implicated in copper homeostasis
  • transiently interacting partner of the PMCA b-splice forms that may play a role in their sorting to or from the plasma membrane
  • PDZD11 was identified as an interacting partner of SLC5A6
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the class I PDZ binding motif identified at the ATP7A C terminus
  • transiently interacting partner of the PMCA b-splice forms that may play a role in their sorting to or from the plasma membrane.
  • interacting partner of SLC5A6 in intestinal epithelial cells and this interaction affects SLC5A6 function and cell biology)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS