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FLASH GENE
Symbol LYZL6 contributors: mct - updated : 27-03-2020
HGNC name lysozyme-like 6
HGNC id 29614
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
two essential catalytic AA conserved in LYZL2 and LYZL6
HOMOLOGY
Homologene
FAMILY c-type lysozyme/alpha-lactalbumin family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
basic FUNCTION
  • play a major role in human reproduction
  • LYZL6 is an antibacterial protein
  • mechanism of antibacterial action of LYZL2 and LYZL6 involved bacterial membrane damage and leakage of cellular contents
  • may have a role in sperm function, innate immunity and other physiological process as well
  • role for LYZL2, LYZL4, LYZL6 in sperm function
  • LYZL2 (basic) and LYZL6 (acidic) possessed intact catalytic residues and could be possessing bacteriolytic activity
  • acidic, bacteriolytic and sperm-related protein, that is likely important for fertilization but not for the innate immunity of the male reproductive tract
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • only LYZL2 and LYZL6 possess peptidoglycan binding ability
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS