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FLASH GENE

Symbol

LYZL6

contributors: mct - updated : 27-03-2020

HGNC name	lysozyme-like 6
HGNC id	29614

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q12      Physical location : 34.261.524 - 34.266.510
Synonym name	lysozyme homolog
Synonym symbol(s)	LYC1, PRO1485, TKAL754, HEL-S-6a, LYZB, UNQ754
EC.number	3.2.1.17

DNA

TYPE	functioning gene
STRUCTURE	9.19 kb     5 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020426 5 - 1074 NP_065159 - 148 - 2017 28182716 NM_001199951 5 - 960 NP_001186880 - 148 - 2017 28182716

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive male system testis       Homo sapiens   male system male genital tract       Homo sapiens   male system male genital tract epididymis     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Reproductive spermatozoa Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		acid
STRUCTURE

motifs/domains

two essential catalytic AA conserved in LYZL2 and LYZL6

HOMOLOGY

Homologene

FAMILY

c-type lysozyme/alpha-lactalbumin family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	play a major role in human reproduction
	LYZL6 is an antibacterial protein
	mechanism of antibacterial action of LYZL2 and LYZL6 involved bacterial membrane damage and leakage of cellular contents
	may have a role in sperm function, innate immunity and other physiological process as well
	role for LYZL2, LYZL4, LYZL6 in sperm function
	LYZL2 (basic) and LYZL6 (acidic) possessed intact catalytic residues and could be possessing bacteriolytic activity
	acidic, bacteriolytic and sperm-related protein, that is likely important for fertilization but not for the innate immunity of the male reproductive tract

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

only LYZL2 and LYZL6 possess peptidoglycan binding ability

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS