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FLASH GENE

Symbol

LYZL2

contributors: mct - updated : 27-03-2020

HGNC name	lysozyme-like 2
HGNC id	29613

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10p11.23      Physical location : 30.900.708 - 30.918.647
Synonym name	lysozyme D2
Synonym symbol(s)	LYZD2
EC.number	3.2.1.17

DNA

TYPE	functioning gene
STRUCTURE	23.54 kb     5 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_183058 5 - 809 NP_898881 - 148 - 2005 16014814

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system breast mammary gland       male system testis       Homo sapiens   male system male genital tract       Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		basic
STRUCTURE

motifs/domains

two essential catalytic AA conserved in LYZL2 and LYZL6

HOMOLOGY

Homologene

FAMILY

c-type lysozyme/alpha-lactalbumin family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	play a major role in human reproduction
	mechanism of antibacterial action of LYZL2 and LYZL6 involved bacterial membrane damage and leakage of cellular contents
	may have a role in sperm function, innate immunity and other physiological process as well
	role for LYZL2, LYZL4, LYZL6 in sperm function
	LYZL2 (basic) and LYZL6 (acidic) possessed intact catalytic residues and could be possessing bacteriolytic activity (pMID: 27832206)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

only LYZL2 and LYZL6 possess peptidoglycan binding ability

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function downregulated in asthenozoospermic condition in human

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS