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FLASH GENE
Symbol LYZL4 contributors: mct - updated : 27-03-2020
HGNC name lysozyme-like 4
HGNC id 28387
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 19 AAs in signal peptide
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,nucleus
    basic FUNCTION
  • plays a physiological role in male reproduction
  • may have a role in sperm function, innate immunity and other physiological process as well
  • role for LYZL2, LYZL4, LYZL6 in sperm function
  • role of SPACA3 and LYZL4 in fertilization
  • contribute likely to fertilization but show no bacteriolytic activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SPACA3, LYZL4 and SPACA5 possess hyaluronan binding ability
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    downregulated in asthenozoospermic condition in human
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • biomarker for male fertility
    • Therapy target
    ANIMAL & CELL MODELS