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FLASH GENE

Symbol

LYZL4

contributors: mct - updated : 27-03-2020

HGNC name	lysozyme-like 4
HGNC id	28387

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis       Homo sapiens   male system male genital tract       Homo sapiens

cell lineage
cell lines
fluid/secretion	sperm

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

19 AAs in signal peptide

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular,nucleus

basic FUNCTION	plays a physiological role in male reproduction
	may have a role in sperm function, innate immunity and other physiological process as well
	role for LYZL2, LYZL4, LYZL6 in sperm function
	role of SPACA3 and LYZL4 in fertilization
	contribute likely to fertilization but show no bacteriolytic activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

SPACA3, LYZL4 and SPACA5 possess hyaluronan binding ability

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function downregulated in asthenozoospermic condition in human

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	biomarker for male fertility
Therapy target

ANIMAL & CELL MODELS