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FLASH GENE
Symbol REEP2 contributors: shn/mct - updated : 25-02-2014
HGNC name receptor accessory protein 2
HGNC id 17975
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide (aa 1–22), a single transmembrane region (aa 42–64) and a leucine-zipper region (aa 167–188)
  • a short extra-cellular N-terminal domain followed by a single transmembrane and a long intracellular domain
    • HOMOLOGY
    interspecies ortholog to Reep2, Rattus norvegicus
    ortholog to Reep2, mus musculus
    ortholog to REEP2, Pan troglodytes
    Homologene
    FAMILY DP1/Yop1p family of ER-shaping proteins
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • enhances the sweetener-responsiveness of endogenously expressed sweet receptors in a chemosensory cell line
  • membrane shaping adapter protein that modulate specific G protein-coupled receptor trafficking by affecting ER cargo capacity
  • implicated in ER Morphogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • T1R2 or T1R3
  • REEP1
  • integral membrane proteins
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG72
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Downregulation of endogenously expressed REEP2 in the chemosensory enteroendocrine GLUTag cell line dramatically reduced sensitivity of endogenous sweet receptors
  • the p.Val36Glu variant has a dominant-negative effect and inhibited the normal binding of wild-type REEP2 to membranes, and the p.Phe72Tyrdecreased the affinity of the mutant protein for membranes
  • REEP2 downregulation leads to expansion of ER sheets in COS7 cells