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FLASH GENE

Symbol

TMEM30B

contributors: mct - updated : 17-01-2015

HGNC name	transmembrane protein 30B
HGNC id	27254

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q23.1      Physical location : 61.744.090 - 61.748.530
Synonym name	cell cycle control protein 50B
Synonym symbol(s)	CDC50B, MGC126775

DNA

TYPE	functioning gene
STRUCTURE	4.44 kb     1 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001017970 1 - 4443 - 351 - 2004 15375526

EXPRESSION

Rna function	mRNA was expressed in pancreatic islet, kidney, prostate as well as in lung carcinoid, parathyroid tumor, bladder tumor, meningioma and pancreatic cancer
Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth         Endocrine pancreas           parathyroid         Respiratory lung           respiratory tract trachea       Urinary kidney

cells

System Cell Pubmed Species Stage Rna symbol Endocrine islet cell (alpha,beta...)

cell lineage
cell lines	in lung carcinoid, parathyroid tumor, bladder tumor, meningioma and pancreatic cancer cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two-transmembrane- doamins

HOMOLOGY

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

components of phospholipid-translocators

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interactions of TMEM30A and TMEM30B with multiple members of the human P(4)-ATPase family, suggesting that these proteins perform broader functions in human physiology than thus far assumed
	ATP8B1 shifted from the endoplasmic reticulum (ER) to the plasma membrane upon coexpression of TMEM30A or TMEM30B
	TMEM30 is not essential for the ER exit or TGN localization of ATP9B, whereas TMEMA, but not TMEM30B, is required for ER exit and/or recycling endosomal localization of ATP11B

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS