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FLASH GENE

Symbol

ZAP70

contributors: mct/npt - updated : 23-06-2016

HGNC name	zeta-chain (TCR) associated protein kinase 70kDa
HGNC id	12858

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

IMD48 , ADMIO2

related resource

ZAP70base: Mutation registry for autosomal recessive ZAP70 immunodeficiency

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function       --over   wth CD38 in chronic lymphocytic leukemia with poor prognosis (el-Sharnouby 2006) tumoral       loss of function results in a severe immunodeficiency, characterized by a lack of mature CD8(+) T cells and non-functional CD4(+) T cells (Picard 2009)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	expression of this protein provides an ideal prognostic marker for chronic lymphocytic leukaemia
Therapy target

ANIMAL & CELL MODELS