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FLASH GENE
Symbol UFM1 contributors: mct - updated : 12-10-2016
HGNC name ubiquitin-fold modifier 1
HGNC id 20597
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two amino acids following a highly conserved glycine in its C terminus , first cleaved to expose its conserved Gly residue, essential for its subsequent conjugating reactions (
    • isoforms Precursor synthesized as an inactive precursor protein composed of 85 AAs
    HOMOLOGY
    Homologene
    FAMILY UFM1 family, ubiquitin-like protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    text
  • Co-localization of UFM1 with DDRGK1 in the endoplasmic reticulum (ER) depends on DDRGK1
    • basic FUNCTION
  • ubiquitin-like modifier protein which binds to a number of as yet unidentified target proteins
  • ubiquitin-like modifier whose conjugation (ufmylation) system is conserved in multicellular organisms
  • UFM1 system, is involved in the regulation of haematopoiesis
  • UFM1-DDRGK1 participate in preventing ER stress-induced apoptosis in protein secretory cells
  • critical insight into the regulatory mechanism of the UFM1 system and established a direct link between this novel UBL system and the ER network
  • UFC1 is one of the enzymes involved in modification of proteins with the ubiquitin-like molecule ubiquitin-fold modifier-1 (UFM1)
  • covalent conjugation of UFM1 to proteins generates a signal that regulates transcription, response to cell stress, and differentiation
  • indispensable role of the UFM1 system in development and hematopoiesis, especially erythroid development
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    UFM1-UBA5-UFC1 ubiquination pathway
    a component
  • components of the UFM1 conjugation pathway (UFM1, DDRGK1, UFL1 and CDK5RAP3)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • covalently attach with cellular protein(s) via a specific E1-activating enzyme (UBA5) and an E2-conjugating enzyme (UFC1)
  • UFL1 is an E3 ligase for UFM1
  • covalently conjugated with DDRGK1
  • CDK5RAP3 interact with UFM1
  • interacting with UBA5 (UBA5, a specific activating enzyme for the ubiquitin-like modifier, UFM1, in erythroid development)
  • UFM1 is activated by the E1 enzyme UBA5, and this pathway is proposed to play an important role in the endoplasmic reticulum (ER) stress response
  • could suppress foam cell formation via the NR1H3-dependent pathway
  • Ufmylation is initiated by UBA5, which activates and transfers UFM1 to ubiquitin-fold modifier-conjugating enzyme 1 (UFC1)
  • UBA5 is an activating enzyme for UFM1
  • UBA5 binds to UFM1 via a trans-binding mechanism in which UFM1 interacts with distinct sites in both subunits of the UBA5 dimer
  • DDRGK1 is an ER membrane protein and a critical component of the ubiquitin-fold modifier 1 (UFM1) system
    • cell & other
    REGULATION
    activated by a novel E1-like activating enzyme, UBA5
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS