protein
| covalently attach with cellular protein(s) via a specific E1-activating enzyme (UBA5) and an E2-conjugating enzyme (UFC1) |
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UFL1 is an E3 ligase for UFM1 |
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covalently conjugated with DDRGK1 |
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CDK5RAP3 interact with UFM1 |
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interacting with UBA5 (UBA5, a specific activating enzyme for the ubiquitin-like modifier, UFM1, in erythroid development) |
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UFM1 is activated by the E1 enzyme UBA5, and this pathway is proposed to play an important role in the endoplasmic reticulum (ER) stress response |
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could suppress foam cell formation via the NR1H3-dependent pathway |
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Ufmylation is initiated by UBA5, which activates and transfers UFM1 to ubiquitin-fold modifier-conjugating enzyme 1 (UFC1) |
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UBA5 is an activating enzyme for UFM1 |
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UBA5 binds to UFM1 via a trans-binding mechanism in which UFM1 interacts with distinct sites in both subunits of the UBA5 dimer |
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DDRGK1 is an ER membrane protein and a critical component of the ubiquitin-fold modifier 1 (UFM1) system |