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FLASH GENE

Symbol

UFM1

contributors: mct - updated : 12-10-2016

HGNC name	ubiquitin-fold modifier 1
HGNC id	20597

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016617 6 - 2618 9.1 85 - 2004 15071506 NM_001286704 6 - 2808 NP_001273633 - 103 - 2004 15071506 NM_001286706 6 - 3306 NP_001273635 - 71 - 2004 15071506 NM_001286705 7 - 2672 NP_001273634 - 71 - 2004 15071506 NM_001286703 6 - 2630 NP_001273632 - 83 - 2004 15071506

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Endocrine pancreas       highly Homo sapiens Hearing/Equilibrium ear inner cochlea   highly Lymphoid/Immune lymph node       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cells

System Cell Pubmed Species Stage Rna symbol Endocrine islet cell (alpha,beta...) Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two amino acids following a highly conserved glycine in its C terminus , first cleaved to expose its conserved Gly residue, essential for its subsequent conjugating reactions (

isoforms

Precursor

synthesized as an inactive precursor protein composed of 85 AAs

HOMOLOGY

Homologene

FAMILY

UFM1 family, ubiquitin-like protein family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,nucleus
text	Co-localization of UFM1 with DDRGK1 in the endoplasmic reticulum (ER) depends on DDRGK1

basic FUNCTION	ubiquitin-like modifier protein which binds to a number of as yet unidentified target proteins
	ubiquitin-like modifier whose conjugation (ufmylation) system is conserved in multicellular organisms
	UFM1 system, is involved in the regulation of haematopoiesis
	UFM1-DDRGK1 participate in preventing ER stress-induced apoptosis in protein secretory cells
	critical insight into the regulatory mechanism of the UFM1 system and established a direct link between this novel UBL system and the ER network
	UFC1 is one of the enzymes involved in modification of proteins with the ubiquitin-like molecule ubiquitin-fold modifier-1 (UFM1)
	covalent conjugation of UFM1 to proteins generates a signal that regulates transcription, response to cell stress, and differentiation
	indispensable role of the UFM1 system in development and hematopoiesis, especially erythroid development

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

UFM1-UBA5-UFC1 ubiquination pathway

a component

components of the UFM1 conjugation pathway (UFM1, DDRGK1, UFL1 and CDK5RAP3)

INTERACTION

DNA

RNA

small molecule

protein	covalently attach with cellular protein(s) via a specific E1-activating enzyme (UBA5) and an E2-conjugating enzyme (UFC1)
	UFL1 is an E3 ligase for UFM1
	covalently conjugated with DDRGK1
	CDK5RAP3 interact with UFM1
	interacting with UBA5 (UBA5, a specific activating enzyme for the ubiquitin-like modifier, UFM1, in erythroid development)
	UFM1 is activated by the E1 enzyme UBA5, and this pathway is proposed to play an important role in the endoplasmic reticulum (ER) stress response
	could suppress foam cell formation via the NR1H3-dependent pathway
	Ufmylation is initiated by UBA5, which activates and transfers UFM1 to ubiquitin-fold modifier-conjugating enzyme 1 (UFC1)
	UBA5 is an activating enzyme for UFM1
	UBA5 binds to UFM1 via a trans-binding mechanism in which UFM1 interacts with distinct sites in both subunits of the UBA5 dimer
	DDRGK1 is an ER membrane protein and a critical component of the ubiquitin-fold modifier 1 (UFM1) system

cell & other

REGULATION

activated by	a novel E1-like activating enzyme, UBA5

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS