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FLASH GENE

Symbol

SPG11

contributors: mct/shn - updated : 14-10-2014

HGNC name	spastic paraplegia 11 (autosomal recessive)
HGNC id	11226

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SPG11 , CMT2X , ALS5

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	SPG11 knock-down in zebrafish by morpholino antisense oligonucleotides lead to locomotor impairment and abnormal branching of spinal cord motor neurons at the neuromuscular junction
	SPG11 knockdown causeS the cation-independent mannose 6-phosphate receptor to become trapped in clusters of early endosomes of HeLa cells