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FLASH GENE
Symbol PEAR1 contributors: mct/pgu - updated : 05-09-2016
HGNC name platelet endothelial aggregation receptor 1
HGNC id 33631
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • multiple EGF-like repeats
  • three fibronectin type-III domains
  • two Ig-like C2-type (immunoglobulin-like) domains
  • a protein kinase domain
    • HOMOLOGY
    intraspecies homolog to MEGF10 and MEGF11 (PMID: 17226770)
    Homologene
    FAMILY TYR protein kinase family, TIE subfamily
    CATEGORY structural protein , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • epidermal growth factor repeat-containing transmembrane receptor, participating in platelet contact-induced activation
  • involved in the fine regulation of the early stages of hematopoietic differentiation, presumably through the Notch signaling pathway
  • platelet transmembrane protein that becomes activated by platelet contact
  • play an important role in agonist-induced platelet aggregation and in the response to aspirin
  • platelet receptor that signals secondary to alpha(IIb)beta(3)-mediated platelet-platelet contacts
  • platelet transmembrane protein that becomes activated by platelet contact
  • appears to play an important role in agonist-induced platelet aggregation and in the response to aspirine
  • PEAR1 an engulfment receptor, and MEGF10, a purported engulfment receptor are expressed in fibroblasts, and facilitated binding to dead neurons
  • PEAR1-induced phagocytosis requires GULP1 binding to clathrin heavy chain (CHC)
  • PEAR1 cell-type specific methylation changes may control long distance interactions with other genes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with GULP1, the mammalian homologue of Ced-6, an adaptor protein required for phagocytosis mediated by the nematode engulfment receptor Ced-1
  • PEAR1 signals through recruitment of GULP1, which promotes phagocytosis through a noncanonical phosphoclathrin-dependent mechanism
  • PEAR1 cell-specific methylation sensitive region in endothelial cells and megakaryocytes that showed strong chromosomal interactions with RRNAD1, MRLP24, HDGF and PRCC
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to variation of platelet aggregability
    Variant & Polymorphism other variant (rs12041331) in intron 1, associated with altered platelet function
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS