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FLASH GENE
Symbol HELT contributors: mct - updated : 11-06-2020
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 849 - 242 - Guimera (2006)
4 - 846 - 241 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainmidbrain   
 brainforebrain   
Reproductivefemale systemovary  lowly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-loop-helix domain
  • orange domain
    • secondary structure bHLH-O
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Helt (91,49 pc)
    Homologene
    FAMILY
  • bHLH-O family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in neuronal differentiation
  • acting as a transcriptional repressor
  • HELT and DLX2 are key transcription factors that are sufficient to direct neuronal progenitors along a specific differentiation pathway at the expense of alternative lineage choices
  • combined activity of two distinct BHLH factors (ASCL1 and HELT) plays likely a key role in the development of discrete classes of thalamic interneurons
  • ASCL1 and HELT factors cooperate synergistically in midbrain GABAergic neurogenesis
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development , nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • binding
    • RNA
    small molecule
    protein
  • homodimerization by the bHLH and Orange domains
  • heterodimerization with Hes5 by the Orange domain
  • heterodimerization with Hey2 by the bHLH domain
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS