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FLASH GENE

Symbol

GKN2

contributors: mct - updated : 16-06-2020

HGNC name	gastrokine 2
HGNC id	24588

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_182536 6 - 723 NP_872342 - 184 - 2009 18722547

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive stomach       predominantly Homo sapiens Respiratory lung         Visual eye retina fovea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory digestive epithelium (mucosa)     Epithelial sensory visual photoreceptor layer

cells

System Cell Pubmed Species Stage Rna symbol Digestive gastric

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

an approximately 100 amino acid BRICHOS domain

HOMOLOGY

intraspecies

homolog to GKN1

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	expression of GKN2 transcript and protein in the visceral endodermal layer and at lower levels in YS endothelial cells

basic FUNCTION	may play a role in gastrointestinal mucosal protection and modulate gut epithelial cell proliferation
	GKN1, GKN2, secreted proteins that are products of gastric mucus-producing cell lineages
	playing likely an important role in extravillous trophoblasts (EVT) physiology
	is a tumor suppressor gene in gastric tumorigenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heterodimer comprises one molecule each of TFF1 and GKN2, and the disulfide bond between TFF1 and GKN2 is the most important factor stabilizing the heterodimer

INTERACTION

DNA

RNA

small molecule

protein	TFF1 protein partner
	gastrointestinal tract specific gene GKN2 might inhibit gastric cancer growth in a TFF1 dependent manner
	GKN2 may contribute to the homeostasis of gastric epithelial cells by inhibiting GKN1 activity
	might inhibit the progression of normal gastric epithelial cells to cancer cells by suppressing NFKB1 signaling pathway, which in turn could be regulated by H. pylori infection (
	interaction between GKN2 and TFF1 can have synergistic antiproliferative and pro-apoptotic effects on gastric cancer
	GKN2 promotes oxidative stress-induced gastric cancer cell apoptosis via the HSPA8 pathway

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   significant reduction of GKN1 and GKN2 genes expression in the cancerous specimens in comparison with the normal tissues constitutional     --over   HELLP placentas showed a tendency of increased levels of GKN2 expression with a more prominent GKN2 staining in their syncytiotrophoblast

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS