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FLASH GENE
Symbol STRA6 contributors: mct/pgu - updated : 22-05-2013
HGNC name stimulated by retinoic acid gene 6 homolog (mouse)
HGNC id 30650
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • between 8 and 12 transmembrane helices
  • HOMOLOGY
    Homologene
    FAMILY
  • stimulated by retinoic acid (STRA) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text
  • induced mitochondria depolarization and accumulation of reactive oxygen species, and was present not only at the cellular membrane but also in the cytosol
  • basic FUNCTION
  • retinol-binding protein receptor may be a component of an as yet unidentified transport machinery
  • involved in vitamin A metabolism, and implicated in anophthalmia and microphthalmia developmental abnormalities
  • multitransmembrane domain protein, and specific membrane receptor for retinol binding protein (RBP)
  • functioning as the high-affinity receptor for plasma retinol binding protein (RBP) and mediates cellular uptake of vitamin A from the vitamin A-RBP complex
  • transmembrane receptor involved in vitamin A uptake, a process essential to eye development and growth
  • transports vitamin A from its blood carrier retinol binding protein (RBP) into cells, and it also functions as a cytokine receptor which activates JAK/STAT signaling
  • appears to be a founding member of a new class of proteins that may be termed "cytokine signaling transporters"
  • catalyzes efficient retinol exchange between intracellular RBP1 and extracellular retinol binding protein, even in the presence of holo-RBP
  • retinoic acid (RA)-inducible gene encoding the cellular receptor for holo-retinol binding protein
  • RBP4 and its membrane receptor STRA6 coordinate cellular retinol uptake
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to RBP with high affinity and has robust vitamin A uptake activity from the vitamin A-RBP complex
  • binds to RBP with high affinity and mediates vitamin A uptake into cells
  • transthyretin blocks retinol uptake and cell signaling by the holo-retinol-binding protein receptor STRA6
  • cell & other
    REGULATION
    activated by DNA damage in a TP53-dependent manner, and it has an important role in cell death responses
    ASSOCIATED DISORDERS
    corresponding disease(s) PAMD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS