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FLASH GENE
Symbol STRA6 contributors: mct/pgu - updated : 22-05-2013
HGNC name stimulated by retinoic acid gene 6 homolog (mouse)
HGNC id 30650
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousnervecranial nerve  highly
Reproductivefemale systemplacenta  highly
 male systemtestis  highly
Visualeyeanterior segment   
 eyeretina   
cells
SystemCellPubmedSpeciesStageRna symbol
ReproductiveSertoli cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • between 8 and 12 transmembrane helices
  • HOMOLOGY
    Homologene
    FAMILY
  • stimulated by retinoic acid (STRA) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text
  • induced mitochondria depolarization and accumulation of reactive oxygen species, and was present not only at the cellular membrane but also in the cytosol
  • basic FUNCTION
  • retinol-binding protein receptor may be a component of an as yet unidentified transport machinery
  • involved in vitamin A metabolism, and implicated in anophthalmia and microphthalmia developmental abnormalities
  • multitransmembrane domain protein, and specific membrane receptor for retinol binding protein (RBP)
  • functioning as the high-affinity receptor for plasma retinol binding protein (RBP) and mediates cellular uptake of vitamin A from the vitamin A-RBP complex
  • transmembrane receptor involved in vitamin A uptake, a process essential to eye development and growth
  • transports vitamin A from its blood carrier retinol binding protein (RBP) into cells, and it also functions as a cytokine receptor which activates JAK/STAT signaling
  • appears to be a founding member of a new class of proteins that may be termed "cytokine signaling transporters"
  • catalyzes efficient retinol exchange between intracellular RBP1 and extracellular retinol binding protein, even in the presence of holo-RBP
  • retinoic acid (RA)-inducible gene encoding the cellular receptor for holo-retinol binding protein
  • RBP4 and its membrane receptor STRA6 coordinate cellular retinol uptake
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to RBP with high affinity and has robust vitamin A uptake activity from the vitamin A-RBP complex
  • binds to RBP with high affinity and mediates vitamin A uptake into cells
  • transthyretin blocks retinol uptake and cell signaling by the holo-retinol-binding protein receptor STRA6
  • cell & other
    REGULATION
    activated by DNA damage in a TP53-dependent manner, and it has an important role in cell death responses
    ASSOCIATED DISORDERS
    corresponding disease(s) PAMD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS